Raiders may be without Brock Bowers in Week 5 against the Colts as a knee issue lingers. His absence could shift more targets to other Raiders receivers and influence game plan and fantasy outcomes.

Colts' depth at cornerback is tested with Kenny Moore sidelined and Xavien Howard retiring; Indianapolis answers with additions and roster moves while Zaire Franklin anchors a growing linebacker corps with a rotating Will position filled by Bachie, Ajiake, and Muma, shaping a Week 5 fantasy landscape on both sides.

Colts elevate veteran Mike Hilton to the active roster and promote Josh Sills as they prepare for the Rams, filling for Kenny Moore II who’s sidelined by an Achilles injury. Hilton could see immediate action, leveraging his Bengals familiarity under Lou Anarumo. Sills adds interior guard depth with Matt Goncalves out toe-wise, while Dalton Tucker logs reps behind him. The move injects veteran stability for Indy’s defense and line in a road test against Los Angeles, with fantasy managers eyeing Hilton’s early snaps and Sills’ potential upside if guard depth shakes out.

Hilton’s fit, coupled with Sills’ depth, could alter weekly rostering for Colts defenders and reserve offensive line options. Look for Hilton to be aligned heavily in the slot and to take on blitz roles, while Sills provides a reliable interior option if Goncalves remains limited. The Rams game becomes a test of Indiana’s veteran reclamation project and how quickly Hilton can translate experience into fantasy points.

Rams return to SoFi Stadium to face an unbeaten Colts led by Daniel Jones and Jonathan Taylor, a pairing that has Indy clicking on offense and bolstering a defense that can pressure. LA must monitor Davante Adams’ hamstring and the health of Higbee as Buckner and company try to melt the Rams’ blocking scheme. The matchup doubles as a fantasy crossroads, with Colts’ skill players offering upside if Jones stays efficient and Rams options shaped by injury reports and game flow.

Fantasy notes center on Jones and Taylor as keys for Indy, Adams and Higbee for LA, and the defensive pieces that could swing scoring. Injuries and game script will decide who emerges as a workable weekly play, with waivers and lineup decisions tight as this clash unfolds in a pivotal week.

Rams try to rebound after a dramatic loss to Philadelphia, facing an unbeat en Colts squad boosted by Jones and Taylor. Jones has found a late-career spark, piling three pass TDs and three rushing TDs with no picks, while Taylor anchors a red-hot offense that’s shown balance and efficiency. The Colts also boast a sturdy defense, sitting seventh in total defense, setting up a tougher-than-expected test for L.A. fantasy managers.

Injury notes cloud the Rams’ potential plays: Adams, Havenstein, Higbee, and Parkinson are all listed as questionable but expected to play, while the Colts’ Buckner is questionable and Moore and Goncalves are dealing with injuries. The matchup pits a Rams club hungry for momentum against a Colts squad with a rhythm that could reshape fantasy rostering this week.

With SoFi Stadium on the line and a schedule shift from a near-miss vs the Eagles to a hot Colts attack, this game could hinge on which offense gets moving first. Expect snaps and targets to swing on the health of key skill players, and a defense that may dominate middle-of-field battles as both teams seek to seize control early.